LIST OF ABBREVIATIONS 4

LIST OF BOXES 6

LIST OF FIGURES 6

LIST OF TABLES 6

EXECUTIVE SUMMARY 7

• 1.INTRODUCTION 9

  1.1. Context and Objectives 9

• 2.UNDERSTANDING OF PATIENT-CENTREDNESS IN HEALTH R&I 11

  2.1. Conceptual and terminological interpretations for patient-centred R&I 11

  2.2. Stakeholder perceptions on patient-centred definitions and principles in the EU 15

• 3.THE VALUE OF PATIENT-CENTREDNESS IN HEALTH R&I 17

• 4.STOCKTAKING OF A FRAGMENTED EU LANDSCAPE 22

  4.1. Patchwork implementation of patient-centredness in health R&I in the EU 22

  4.2. Implementation experiences in patient-centred health R&I 26

  4.3. Disease-specific initiatives in advancing patient-centred health R&I in the EU 28

  4.3.1. Multiple Sclerosis 28

  4.3.2. Cancer 29

  4.4. Patient-Centredness in EU Health R&I Infrastructure 31

  4.5. EU health R&I funding instruments and patient-centredness 34

  4.5.1. Horizon Europe 36

  4.5.2. Innovative Health Initiative 38

  4.5.3. EU4Health 41

• 5.EU MEMBER STATE CASE STUDIES 43

  5.1. Germany 44

  5.2. The Netherlands 49

  5.3. Belgium 53

• 6.REFLECTIONS AND RECOMMENDATIONS 58

  6.1. National best practices that could be scaled up at the EU level 58

  6.2. Recommendations on strengthening patient-centric health R&I in the EU 61

REFERENCES 67

ANNEX 83

Methods 83

Limitations 84